Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats.
Ketamine has gained significant attention as a fast-acting antidepressant.However, ketamine is also associated with undesirable side effects.In our preclinical study, we explored the behavioral effects of ketamine enantiomers at subanesthetic doses.During repeated intermittent treatment, we examined locomotor stimulation and sensitization, ataxia,